GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6479891 | 1 | rs7081275 | chr10:65106551 | LOC84989 | chr10:65224989-65226320:+ | -0.27 | -4.39 | 1.39E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs7081275 | chr10:65106551 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -4.77 | 2.5E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs7078219 | 1 | rs7081330 | chr10:101274465 | NKX2-3 | chr10:101292690-101296278:+ | -0.32 | -5.68 | 2.39E-8 | Dental caries |
| THCA | cis | rs10741243 | 1 | rs7081792 | chr10:132948840 | TCERG1L | chr10:132890656-133109984:- | 0.4 | 6.04 | 3.08E-9 | Type 2 diabetes |
| THCA | cis | rs708224 | 1 | rs708224 | chr12:32436409 | BICD1 | chr12:32260185-32531140:+ | 0.12 | 3.94 | 9.39E-5 | Pancreatic cancer |
| THCA | cis | rs708224 | 1 | rs708224 | chr12:32436409 | FGD4 | chr12:32638906-32798982:+ | 0.15 | 4.14 | 4.1E-5 | Pancreatic cancer |
| THCA | cis | rs12780845 | 1 | rs7082376 | chr10:17232223 | TRDMT1 | chr10:17184983-17243681:- | -0.45 | -10.34 | 9.33E-23 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs7082376 | chr10:17232223 | VIM | chr10:17270258-17279592:+ | -0.19 | -3.49 | 0.000532 | Homocysteine levels |
| THCA | cis | rs6602175 | 1 | rs7083655 | chr10:17142702 | CUBN | chr10:16865966-17171816:- | 0.21 | 4.89 | 1.37E-6 | Whole-brain volume |
| THCA | cis | rs12780845 | 1 | rs7084476 | chr10:17211383 | TRDMT1 | chr10:17184983-17243681:- | -0.43 | -10.12 | 5.94E-22 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs7084476 | chr10:17211383 | VIM | chr10:17270258-17279592:+ | -0.18 | -3.42 | 0.000688 | Homocysteine levels |
| THCA | cis | rs11190604 | 1 | rs7084810 | chr10:102297546 | SEC31B | chr10:102246403-102289636:- | -0.28 | -8.96 | 7.03E-18 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs11014306 | 1 | rs7084900 | chr10:25201585 | PRTFDC1 | chr10:25137554-25241533:- | 0.25 | 3.43 | 0.000644 | Metabolite levels (Pyroglutamine) |
| THCA | cis | rs7084921 | 1 | rs7084921 | chr10:101813802 | CWF19L1 | chr10:101992055-102027437:- | 0.43 | 7.84 | 2.88E-14 | Bone mineral density |
| THCA | cis | rs11190604 | 1 | rs7085439 | chr10:102210100 | SEC31B | chr10:102246403-102289636:- | -0.3 | -10.17 | 3.96E-22 | Palmitoleic acid (16:1n-7) plasma levels |